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Some people still believe that even higher doses, 5,000 or 10,000 IU, may lead to some benefits, but this is not scientifically proven, he added

Studies suggest that various molecular pathways are involved in IC/BPS, including the JUN N-terminal kinase (JNK) pathway, transient receptor potential (TRP) channels, activated mast cells, mucosal signalling, circadian rhythm regulation, inflammation and neural dysregulation

For example, ZNF498 inhibits Ser46 phosphorylation to reduce p53 transcription in hepatocellular carcinoma (Zhang et al., 2022)

The Journal of clinical endocrinology and metabolism, 91(12), 47924797